In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-Thioguanine; NSC 752 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time alkali diluted with saline 100.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on day 5
Q01DX001 (ip) median survival time alkali diluted with saline 125.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/10 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 10.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with water 20.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 20.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 40.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 40.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 80.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 80.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 160.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean survival time alkali diluted with water 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5
Q01DX009 (ip) mean survival time alkali diluted with saline 9.38 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q01DX009 (ip) mean survival time alkali diluted with saline 18.8 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q01DX009 (ip) mean survival time alkali diluted with saline 37.5 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q01DX009 (ip) mean survival time alkali diluted with saline 75.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q01DX009 (ip) mean survival time alkali diluted with saline 150.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5