In Vivo Screening Data Summary

NCI In Vivo Screening Data

CA 755 resistant to 6-Mercaptopurine; NSC 755 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.25 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.0 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 4.0 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 8.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 16.0 mg/kg/injection 22.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.1 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.5 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.5 mg/kg/injection 84.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.5 mg/kg/injection 186.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.9 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.9 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.25 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.8 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.8 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.0 mg/kg/injection 63.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 39.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 69.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.5 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.5 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.5 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.5 mg/kg/injection 56.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.5 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 4.0 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 79.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 79.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 63.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.0 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.0 mg/kg/injection 42.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.0 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.0 mg/kg/injection 26.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 54.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 63.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.0 mg/kg/injection 12.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.0 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.0 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 20.0 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 20.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 20.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 18.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 40.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 12; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 40.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 02/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 56.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)