In Vivo Screening Data Summary

NCI In Vivo Screening Data

CA 755 resistant to 6-Mercaptopurine; NSC 755 (subcutaneous) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight saline 2.5 mg/kg/injection 84.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 5.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 10.0 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 10.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 10.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 10.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 20.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 20.0 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 20.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 30.0 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 12; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 2.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 4.0 mg/kg/injection 54.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 22.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (oral) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 12; 13/13 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (oral) mean tumor weight carboxymethylcellulose (CMC) 10.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 12; 13/13 animals surviving on tox evaluation day (usually day 5)