In Vivo Screening Data Summary

NCI In Vivo Screening Data

P1798 resistant to Cortisone; NSC 9703 (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 34.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 68.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 135.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight alkali diluted with saline 10.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight alkali diluted with saline 20.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight alkali diluted with saline 40.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight alkali diluted with saline 80.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 12; 04/06 animals surviving on tox evaluation day (usually day 5)