In Vivo Screening Data Summary

NCI In Vivo Screening Data

P1798 Lymphosarcoma (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 34.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 68.0 mg/kg/injection 134.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean tumor weight carboxymethylcellulose (CMC) 135.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 3.12 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 18.3 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 18.3 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 18.3 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 18.7 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 69.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 37.5 mg/kg/injection 53.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 37.5 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 37.5 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 37.5 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 75.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 75.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 14; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 75.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 01/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 75.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 14; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 300.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/10 animals surviving on tox evaluation day (usually day 5)