In Vivo Screening Data Summary

NCI In Vivo Screening Data

S-91 Cloudman Melanotic Melanoma (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight other 12.5 mg/kg/injection 80.0 Antitumor endpoint evaluated on day 28; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 12.5 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 26; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 25.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 25.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 26; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 25.0 mg/kg/injection 75.0 Antitumor endpoint evaluated on day 28; 11/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 25.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 21; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 50.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 50.0 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 26; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 50.0 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 28; 11/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 50.0 mg/kg/injection 55.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 100.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 21; 07/10 animals surviving on tox evaluation day (usually day 5)