In Vivo Screening Data Summary

NCI In Vivo Screening Data

C1498 Myeloid Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) median survival time other 1.25 mg/kg/injection 104.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time other 2.5 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time other 5.0 mg/kg/injection 109.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time other 10.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)