In Vivo Screening Data Summary

NCI In Vivo Screening Data

ADJ-PC-20 Plasma Cell (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) mean tumor weight other 3.1 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.2 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 21; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 18.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 21; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 21; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 21; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 6.25 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 12.5 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 25.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 50.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 21; 03/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/06 animals surviving on tox evaluation day (usually day 5)