In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lieberman Plasma Cell No. 1 (LPC-1) (intraperitoneal) in CAF1 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX028 (sc) median survival time other 14.0 mg/kg/injection 112.0 Experiment continued until the death of all animals; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX028 (sc) median survival time other 23.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX028 (sc) median survival time other 39.0 mg/kg/injection 107.0 Experiment continued until the death of all animals; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX028 (sc) median survival time other 65.0 mg/kg/injection 109.0 Experiment continued until the death of all animals; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX028 (sc) median survival time other 108.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/10 animals surviving on tox evaluation day (usually day 5)