In Vivo Screening Data Summary

NCI In Vivo Screening Data

ADJ-PC-5 Plasma Cell (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) mean tumor weight other 0.31 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 21; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 21; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 21; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 21; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 21; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 21; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 6.25 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 12.5 mg/kg/injection 8.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (none) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 18; 00/06 animals surviving on tox evaluation day (usually day 5)