In Vivo Screening Data Summary

NCI In Vivo Screening Data

ADJ-PC-6 (intraperitoneal) in BALB/cJ mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median survival time alkali diluted with saline 10.0 mg/kg/injection 335.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 335.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 25.0 mg/kg/injection 471.0 Antitumor endpoint evaluated on day 90; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 335.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 471.0 Antitumor endpoint evaluated on day 90; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 335.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 100.0 mg/kg/injection 471.0 Antitumor endpoint evaluated on day 90; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 100.0 mg/kg/injection 178.0 Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 335.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 90; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 90; 03/08 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with saline 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 75; 01/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 100.0 mg/kg/injection 275.0 Antitumor endpoint evaluated on day 85; 10/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 100.0 mg/kg/injection 283.0 Antitumor endpoint evaluated on day 75; 09/09 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 200.0 mg/kg/injection 275.0 Antitumor endpoint evaluated on day 85; 10/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 200.0 mg/kg/injection 369.0 Antitumor endpoint evaluated on day 75; 09/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 85; 10/10 animals surviving on day 9
Q04DX003 (ip) median survival time alkali diluted with water 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 75; 10/10 animals surviving on day 9