In Vivo Screening Data Summary

NCI In Vivo Screening Data

Nontumored Animals (Toxicity Test) in CD2F1 (CDF1) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time saline 150.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 150.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 175.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 175.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 200.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 200.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 225.0 mg/kg/injection NA 09/09 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 225.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) survival time, mean or median saline 50.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) survival time, mean or median saline 100.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) survival time, mean or median saline 200.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) survival time, mean or median saline 400.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 5.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 10.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 12.5 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 20.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 25.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 40.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 50.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) survival time, mean or median saline 100.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 5.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 5.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 13.2 mg/kg/injection NA 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 13.2 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 13.3 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 25.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 25.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 27.0 mg/kg/injection NA 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 27.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection NA 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) survival time, mean or median saline 6.25 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) survival time, mean or median saline 12.5 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) survival time, mean or median saline 25.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) survival time, mean or median saline 50.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) survival time, mean or median saline 12.5 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) survival time, mean or median saline 25.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) survival time, mean or median saline 50.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) survival time, mean or median saline 100.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 1.88 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 3.75 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 7.5 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 15.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 17.8 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 26.7 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 29.6 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 40.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 40.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 40.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 44.4 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 67.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 80.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 80.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 90.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 90.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 90.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 90.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 90.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 120.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 120.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 150.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) survival time, mean or median saline 25.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) survival time, mean or median saline 50.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) survival time, mean or median saline 100.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) survival time, mean or median saline 200.0 mg/kg/injection NA 08/08 animals surviving on tox evaluation day (usually day 5)