In Vivo Screening Data Summary

NCI In Vivo Screening Data

Nontumored Animals (Toxicity Test) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time alkali diluted with water 100.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with water 167.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with water 278.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 15.6 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 25.9 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 43.2 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 72.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 120.0 mg/kg/injection NA 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time Klucel (hydroxypropylcellulose) (HPC) 22.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time Klucel (hydroxypropylcellulose) (HPC) 33.0 mg/kg/injection NA 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection NA 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 43.2 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 72.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 120.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 200.0 mg/kg/injection NA 04/04 animals surviving on tox evaluation day (usually day 5)