In Vivo Screening Data Summary

NCI In Vivo Screening Data

ADJ-PC-22 Plasma Cell (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) mean tumor weight other 0.3 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 27; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 0.7 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 1.5 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 1.56 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 3.12 mg/kg/injection 11.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 3.12 mg/kg/injection 2.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 27; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 12.0 Antitumor endpoint evaluated on day 27; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 8.0 Antitumor endpoint evaluated on day 27; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 27; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 27; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 27; 00/06 animals surviving on tox evaluation day (usually day 5)