In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lymphoma AKR (Transplanted) (intraperitoneal) in AKR/Lw mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time saline 30.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 30.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 30.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 60.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 60.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 60.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 75.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 120.0 mg/kg/injection 222.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 120.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 120.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 150.0 mg/kg/injection 128.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 200.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 300.0 mg/kg/injection 119.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 300.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 400.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 150.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 150.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 175.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 175.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 300.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 300.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 600.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 37.5 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 50.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 60.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 75.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 75.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 80.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 80.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 100.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 100.0 mg/kg/injection 130.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 150.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 200.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 30.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection 119.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 120.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 200.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 65.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 125.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 135.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 121.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)