In Vivo Screening Data Summary

NCI In Vivo Screening Data

B16 Melanoma (intramuscular) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time other 11.3 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 22.5 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 45.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 90.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 00/10 animals surviving on tox evaluation day (usually day 5)