In Vivo Screening Data Summary

NCI In Vivo Screening Data

B16 Melanoma (intraperitoneal) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time saline 7.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 7.5 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 30.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 60.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)