In Vivo Screening Data Summary

NCI In Vivo Screening Data

B16 Melanoma (intraperitoneal) in B6C3F1 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 7.5 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)