In Vivo Screening Data Summary

NCI In Vivo Screening Data

B16 Melanoma (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 147.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 169.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 128.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline with Tween-80 25.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 24; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline with Tween-80 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 24; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline with Tween-80 100.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 24; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline with Tween-80 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 24; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 400.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 158.0 Antitumor endpoint evaluated on day 14; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 82.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 18; 03/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) saline with Tween-80 25.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 15; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) saline with Tween-80 50.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 15; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median tumor weight (est.) saline with Tween-80 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 15; 02/06 animals surviving on tox evaluation day (usually day 5)