In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon 26 Adenocarcinoma (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 128.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 164.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 143.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 252.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 191.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 171.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 141.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 70; 01/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 70; 10/10 animals surviving on tox evaluation day (usually day 5)