In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 169105
CAS 62-31-7
Dopamine hydrochloride; P 498; Dynatra

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 112.5 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 225.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 225.0 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 450.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 450.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 900.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 900.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20