In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 7.5 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 7.5 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 7.5 mg/kg/injection 74.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 82.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 59.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 05/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 69.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX003 (ip) median tumor weight (est.) saline with Tween-80 7.5 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 20; 05/05 animals surviving on tox evaluation day (usually day 5)
Q07DX003 (ip) median tumor weight (est.) saline with Tween-80 15.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 20; 06/06 animals surviving on tox evaluation day (usually day 5)
Q07DX003 (ip) median tumor weight (est.) saline with Tween-80 30.0 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 20; 04/06 animals surviving on tox evaluation day (usually day 5)