In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon Carcinoma 38 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 54.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 126.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 54.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 58.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 63.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 05/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 57.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 13.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 15.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20