In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon Carcinoma 38 (subcutaneous) in B6C3F1 mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX006 (ip) median tumor weight (est.) saline 24.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 23; 07/09 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) median tumor weight (est.) saline 36.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 23; 08/10 animals surviving on tox evaluation day (usually day 5)
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 11.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 176.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 84.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 20; 09/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.7 mg/kg/injection 79.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 8.75 mg/kg/injection 59.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 55.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 126.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 165.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 20; 09/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 17.5 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 58.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 35.0 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 70.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 20; 08/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) saline 140.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 05/10 animals surviving on day 20
Q07DX002 (ip) optimum tumor weight change saline 35.0 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 35
Q07DX002 (ip) optimum tumor weight change saline 70.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 35
Q07DX002 (ip) optimum tumor weight change saline 140.0 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 35