In Vivo Screening Data Summary

NCI In Vivo Screening Data

Colon Carcinoma 38 (subcutaneous) in B6C3F1 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 39.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 79.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 26.0 Antitumor endpoint evaluated on day 20; 09/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 18.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 58.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 54.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 124.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 05/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 76.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 82.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 46.0 Antitumor endpoint evaluated on day 20; 09/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 06/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 20; 10/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 20; 07/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 03/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 04/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 01/09 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 00/10 animals surviving on day 20
Q07DX002 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 20; 02/10 animals surviving on day 20