In Vivo Screening Data Summary

NCI In Vivo Screening Data

Adenocarcinoma 755 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 48985
CAS 53-36-1
D-Med; U 8210; Mepred

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (sc) mean tumor weight steriod suspending solution 2.5 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 3.8 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 5.0 mg/kg/injection 57.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 7.5 mg/kg/injection 68.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 10.0 mg/kg/injection 35.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 15.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 20.0 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 20.0 mg/kg/injection 25.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 40.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 40.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 12; 11/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 06/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 80.0 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 11/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (sc) mean tumor weight steriod suspending solution 320.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 04/12 animals surviving on tox evaluation day (usually day 5)