In Vivo Screening Data Summary

NCI In Vivo Screening Data

Adenocarcinoma 755 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 54114
CAS 1187-58-2
N-Methylpropanamide; N-Methylpropionamide; N-Methylpropionic acid amide

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight saline 45.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 90.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 175.0 mg/kg/injection 81.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight saline 350.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1000.0 mg/kg/injection 11.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1250.0 mg/kg/injection 63.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1250.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1500.0 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1560.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 1750.0 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X022 (ip) mean tumor weight other 625.0 mg/kg/injection 6.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)