| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX001 (oral) | mean tumor weight | alkali diluted with saline | 320.0 mg/kg/injection | 11.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (oral) | mean tumor weight | alkali diluted with saline | 480.0 mg/kg/injection | 8.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (oral) | mean tumor weight | alkali diluted with saline | 640.0 mg/kg/injection | 9.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX001 (oral) | mean tumor weight | alkali diluted with saline | 960.0 mg/kg/injection | 11.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 2.5 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 5.0 mg/kg/injection | 8.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 5.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 5.0 mg/kg/injection | 13.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 10.0 mg/kg/injection | 7.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 10.0 mg/kg/injection | 7.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 10.0 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 10.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 10.0 mg/kg/injection | 5.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 15.0 mg/kg/injection | 6.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 20.0 mg/kg/injection | 3.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 20.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 12; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 06/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 20.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 20.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | saline | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 41.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 40.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 52.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 77.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 60.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 0.5 mg/kg/injection | 47.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 24.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 32.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 19.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 10.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 15.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.0 mg/kg/injection | 15.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 1.5 mg/kg/injection | 26.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 16.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 25.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 17.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 3.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.0 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 2.5 mg/kg/injection | 7.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 5.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 5.0 mg/kg/injection | 30.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 6.0 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 20.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 03/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 40.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | carboxymethylcellulose (CMC) | 50.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 00/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | carboxymethylcellulose (CMC) | 5.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 12; 13/13 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | alkali diluted with saline | 20.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | alkali diluted with saline | 40.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | alkali diluted with saline | 80.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | alkali diluted with saline | 80.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 05/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (oral) | mean tumor weight | alkali diluted with saline | 160.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 02/10 animals surviving on tox evaluation day (usually day 5) |
| Q02DX006 (ip) | mean tumor weight | other | 10.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q02DX006 (ip) | mean tumor weight | other | 20.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q02DX006 (ip) | mean tumor weight | other | 30.0 mg/kg/injection | 3.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q03DX004 (oral) | mean tumor weight | alkali diluted with saline | 320.0 mg/kg/injection | 1.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q03DX004 (oral) | mean tumor weight | alkali diluted with saline | 640.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (oral) | mean tumor weight | alkali diluted with saline | 320.0 mg/kg/injection | 5.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (oral) | mean tumor weight | alkali diluted with saline | 480.0 mg/kg/injection | 4.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (oral) | mean tumor weight | alkali diluted with saline | 640.0 mg/kg/injection | 2.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q07DX002 (oral) | mean tumor weight | alkali diluted with saline | 960.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 12; 03/10 animals surviving on tox evaluation day (usually day 5) |