In Vivo Screening Data Summary

NCI In Vivo Screening Data

Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) mean tumor weight saline 15.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 28; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean tumor weight saline 30.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 28; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean tumor weight saline 60.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 28; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) mean tumor weight saline 35.0 mg/kg/injection 136.0 Antitumor endpoint evaluated on day 33; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) mean tumor weight saline 67.5 mg/kg/injection 57.0 Antitumor endpoint evaluated on day 33; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) mean tumor weight saline 135.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 33; 07/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 4.0 mg/kg/injection 73.0 Antitumor endpoint evaluated on day 33; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 8.0 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 33; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 16.0 mg/kg/injection 350.0 Antitumor endpoint evaluated on day 33; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 32.0 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 33; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 64.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 33; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) saline 128.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 33; 08/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 80.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) median tumor weight (est.) Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 17.0 Antitumor endpoint evaluated on day 30; 08/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) mean tumor weight (est.) sodium bicarbonate 67.5 mg/kg/injection 136.0 Antitumor endpoint evaluated on day 63; 08/10 animals surviving on tox evaluation day (usually day 5)
Q07DX005 (ip) mean tumor weight (est.) sodium bicarbonate 135.0 mg/kg/injection 42.0 Antitumor endpoint evaluated on day 63; 04/10 animals surviving on tox evaluation day (usually day 5)
Q07DX006 (ip) mean tumor weight sodium bicarbonate 67.5 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 37; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX006 (ip) mean tumor weight sodium bicarbonate 135.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 37; 02/10 animals surviving on tox evaluation day (usually day 5)
Q07DX007 (ip) mean tumor weight saline 35.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 44; 10/10 animals surviving on tox evaluation day (usually day 5)
Q07DX007 (ip) mean tumor weight saline 67.5 mg/kg/injection 81.0 Antitumor endpoint evaluated on day 44; 09/10 animals surviving on tox evaluation day (usually day 5)
Q07DX007 (ip) mean tumor weight saline 135.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 44; 06/10 animals surviving on tox evaluation day (usually day 5)