In Vivo Screening Data Summary

NCI In Vivo Screening Data

Ependymoblastoma (intracerebral) in C57BL/6 mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) median survival time saline 3.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline 6.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline 12.0 mg/kg/injection 132.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline 24.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline 48.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.12 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.25 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.5 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 1.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 1.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 2.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 2.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 4.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 4.0 mg/kg/injection 158.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 8.0 mg/kg/injection 237.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 16.0 mg/kg/injection 297.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 0.5 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 1.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 2.0 mg/kg/injection 147.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 4.0 mg/kg/injection 216.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 8.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 8.0 mg/kg/injection 295.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 12.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 16.0 mg/kg/injection 294.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 18.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)