In Vivo Screening Data Summary

NCI In Vivo Screening Data

Ependymoblastoma (intracerebral) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 140.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 135.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 158.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 2.5 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 5.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 10.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline with Tween-80 20.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)