In Vivo Screening Data Summary

NCI In Vivo Screening Data

Ependymoblastoma (intracerebral) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 10.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 20.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)