In Vivo Screening Data Summary

NCI In Vivo Screening Data

Friend Virus Leukemia (Solid) (subcutaneous) in B6D2F1 (BDF1) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.0 mg/kg/injection 84.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.3 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.0 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.7 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.8 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 08/09 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 13.5 mg/kg/injection 69.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 13.5 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 18.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 24.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 12; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 24.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 24.0 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 24.0 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 24.0 mg/kg/injection 25.0 Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 27.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 27.0 mg/kg/injection 22.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)