In Vivo Screening Data Summary

NCI In Vivo Screening Data

Friend Virus Leukemia (Solid) (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.03 mg/kg/injection 55.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.05 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.1 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.1 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.1 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 0.1 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 37.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 1.0 mg/kg/injection 82.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.5 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 2.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 12.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 5.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.0 mg/kg/injection 13.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.0 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.0 mg/kg/injection 9.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 11.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 28.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 42.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 42.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight carboxymethylcellulose (CMC) 42.0 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5)