In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lymphosarcoma Gardner 6C3HED (intraperitoneal) in C3H/He mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time saline 13.3 mg/kg/injection 222.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 222.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 27.0 mg/kg/injection 203.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median saline 5.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median saline 10.0 mg/kg/injection 143.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median saline 20.0 mg/kg/injection 283.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) survival time, mean or median saline 40.0 mg/kg/injection 203.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)