In Vivo Screening Data Summary

NCI In Vivo Screening Data

HL-60 Human Promyelocytic Leukemia Xenograft (intraperitoneal) in NU/NU Swiss (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.13 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.2 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 9
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 0.3 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on day 9