In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H23 Human Lung Adenocarcinoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX004 (ip) mean tumor weight change saline 50.0 mg/kg/injection 31.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 50.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 75.0 mg/kg/injection -79.0 Antitumor endpoint evaluated on day 18; 04/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 75.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 112.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 18; 00/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline 112.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 18; 04/06 animals surviving on day 18