In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H23 Human Lung Adenocarcinoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX004 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 4.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 2.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline with Tween-80 12.0 mg/kg/injection -26.0 Antitumor endpoint evaluated on day 18; 05/05 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline with Tween-80 18.0 mg/kg/injection -56.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18
Q04DX004 (ip) mean tumor weight change saline with Tween-80 27.0 mg/kg/injection -100.0 Antitumor endpoint evaluated on day 18; 06/06 animals surviving on day 18