In Vivo Screening Data Summary

NCI In Vivo Screening Data

NCI-H520 Human Lung Squamous Cell Carcinoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change saline 50.0 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 75.0 mg/kg/injection 60.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on day 14
Q04DX003 (ip) mean tumor weight change saline 112.0 mg/kg/injection 26.0 Antitumor endpoint evaluated on day 14; 05/06 animals surviving on day 14