In Vivo Screening Data Summary

NCI In Vivo Screening Data

DU145 Human Prostate Tumor (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 22.0 Antitumor endpoint evaluated on day 13; 05/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 52.0 Antitumor endpoint evaluated on day 13; 05/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 59.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 50.0 Antitumor endpoint evaluated on day 13; 05/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 22.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection -41.0 Antitumor endpoint evaluated on day 13; 06/06 animals surviving on day 13