In Vivo Screening Data Summary

NCI In Vivo Screening Data

AK4 Lymphoid Leukemia (intraperitoneal) in C3AKF1 (CHKRF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) median survival time alkali diluted with saline 5.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 5.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 10.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 10.0 mg/kg/injection 118.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 112.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 131.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 5.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 5.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 10.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 10.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 20.0 mg/kg/injection 90.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 20.0 mg/kg/injection 106.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 40.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 40.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 80.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time saline 80.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)