In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to DTIC; NSC 45388 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time other 25.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 50.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 100.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX017 (ip) median survival time other 12.5 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 54; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX017 (ip) median survival time other 25.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 54; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX017 (ip) median survival time other 50.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 54; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX017 (ip) median survival time other 100.0 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 54; 08/08 animals surviving on tox evaluation day (usually day 5)