In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia (intracerebral) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) mean survival time alkali diluted with saline 60.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 90.0 mg/kg/injection 117.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 135.0 mg/kg/injection 115.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (oral) median survival time saline with Tween-80 100.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (oral) median survival time saline with Tween-80 200.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (oral) median survival time saline with Tween-80 400.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (oral) median survival time saline with Tween-80 800.0 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (oral) median survival time saline with Tween-80 1600.0 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 126.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 136.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 141.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 181.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 6.0 mg/kg/injection 114.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 9.0 mg/kg/injection 120.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 14.0 mg/kg/injection 120.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)