In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia (subcutaneous) in CD2F1 (CDF1) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time saline 50.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 100.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 200.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time saline 400.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) median survival time saline 12.5 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) median survival time saline 25.0 mg/kg/injection 144.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) median survival time saline 50.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX006 (ip) median survival time saline 100.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 2.5 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 2.5 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 5.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 5.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 6.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 6.25 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 10.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 12.0 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 12.5 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 16.0 mg/kg/injection 136.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 153.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 141.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 20.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 24.0 mg/kg/injection 139.0 Antitumor endpoint evaluated on day 40; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 24.0 mg/kg/injection 155.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 25.0 mg/kg/injection 143.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 36.0 mg/kg/injection 132.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 114.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 40.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 48.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 40; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 50.0 mg/kg/injection 150.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 80.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time saline 96.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 6.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 10.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 12.0 mg/kg/injection 126.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 16.0 mg/kg/injection 150.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 20.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 24.0 mg/kg/injection 152.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 24.0 mg/kg/injection 168.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 26.7 mg/kg/injection 152.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 36.0 mg/kg/injection 143.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 40.0 mg/kg/injection 151.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 40.0 mg/kg/injection 160.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 48.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 60.0 mg/kg/injection 161.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 80.0 mg/kg/injection 138.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 80.0 mg/kg/injection 143.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 96.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 160.0 mg/kg/injection 130.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 160.0 mg/kg/injection 134.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline 240.0 mg/kg/injection 132.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time saline 23.0 mg/kg/injection 133.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time saline 39.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time saline 65.0 mg/kg/injection 112.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time saline 108.0 mg/kg/injection 112.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time saline 180.0 mg/kg/injection 108.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) median survival time saline 12.5 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) median survival time saline 25.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) median survival time saline 50.0 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q02DX005 (ip) median survival time saline 100.0 mg/kg/injection 175.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 25.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 50.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 155.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 200.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)