In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia (subcutaneous) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (sc) median survival time other 39.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (sc) median survival time other 65.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (sc) median survival time other 108.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (sc) median survival time other 180.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (sc) median survival time other 300.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 5.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 10.0 mg/kg/injection 142.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 20.0 mg/kg/injection 167.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 40.0 mg/kg/injection 151.0 Antitumor endpoint evaluated on day 30; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 80.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (sc) median survival time saline with Tween-80 160.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 30; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 14.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 23.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 39.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 65.0 mg/kg/injection 145.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 108.0 mg/kg/injection 175.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) median survival time other 180.0 mg/kg/injection 130.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 14.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 23.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 23.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 23.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 23.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 25.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 23; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 39.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 39.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 39.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 39.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 46.8 mg/kg/injection 122.0 Experiment continued until the death of all animals; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 50.0 mg/kg/injection 175.0 Antitumor endpoint evaluated on day 23; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 65.0 mg/kg/injection 154.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 65.0 mg/kg/injection 120.0 Experiment continued until the death of all animals; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 65.0 mg/kg/injection 130.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 65.0 mg/kg/injection 166.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 78.0 mg/kg/injection 194.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 100.0 mg/kg/injection 162.0 Antitumor endpoint evaluated on day 23; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 108.0 mg/kg/injection 163.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 108.0 mg/kg/injection 170.0 Experiment continued until the death of all animals; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 108.0 mg/kg/injection 180.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 108.0 mg/kg/injection 177.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 130.0 mg/kg/injection 177.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 180.0 mg/kg/injection 145.0 Experiment continued until the death of all animals; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 180.0 mg/kg/injection 180.0 Experiment continued until the death of all animals; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 180.0 mg/kg/injection 130.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 180.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 200.0 mg/kg/injection 137.0 Antitumor endpoint evaluated on day 23; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 216.0 mg/kg/injection 166.0 Experiment continued until the death of all animals; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 300.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 04/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 300.0 mg/kg/injection 150.0 Experiment continued until the death of all animals; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 5.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 03/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 8.4 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 8.4 mg/kg/injection 0.0 Experiment continued until the death of all animals; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 14.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 14.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 02/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 23.0 mg/kg/injection 109.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 23.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 39.0 mg/kg/injection 136.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 39.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 65.0 mg/kg/injection 131.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 65.0 mg/kg/injection 165.0 Experiment continued until the death of all animals; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 108.0 mg/kg/injection 118.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 108.0 mg/kg/injection 150.0 Experiment continued until the death of all animals; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 180.0 mg/kg/injection 118.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 180.0 mg/kg/injection 140.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time methylcellulose (MC) 300.0 mg/kg/injection 130.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (oral) median survival time other 23.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (oral) median survival time other 39.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (oral) median survival time other 65.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (oral) median survival time other 108.0 mg/kg/injection 170.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (oral) median survival time other 180.0 mg/kg/injection 145.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX Z (sc) median survival time other 23.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX Z (sc) median survival time other 39.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX Z (sc) median survival time other 65.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX Z (sc) median survival time other 108.0 mg/kg/injection 200.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q02DX Z (sc) median survival time other 180.0 mg/kg/injection 172.0 Experiment continued until the death of all animals; 07/08 animals surviving on tox evaluation day (usually day 5)
Q07DX Z (sc) median survival time other 39.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q07DX Z (sc) median survival time other 65.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q07DX Z (sc) median survival time other 108.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q07DX Z (sc) median survival time other 180.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q07DX Z (sc) median survival time other 300.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 04/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 5.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 8.4 mg/kg/injection 138.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 14.0 mg/kg/injection 172.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 23.0 mg/kg/injection 161.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 39.0 mg/kg/injection 144.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 65.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 108.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q## X Z (sc) median survival time other 180.0 mg/kg/injection 122.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q#A X Z (sc) median survival time other 14.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q#A X Z (sc) median survival time other 23.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q#A X Z (sc) median survival time other 39.0 mg/kg/injection 166.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q#A X Z (sc) median survival time other 65.0 mg/kg/injection 177.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)
Q#A X Z (sc) median survival time other 108.0 mg/kg/injection 144.0 Experiment continued until the death of all animals; 08/08 animals surviving on tox evaluation day (usually day 5)