In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to Cyclocytidine; NSC 145668 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time water 25.0 mg/kg/injection 144.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time water 50.0 mg/kg/injection 172.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time water 100.0 mg/kg/injection 155.0 Antitumor endpoint evaluated on day 30; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time water 200.0 mg/kg/injection 133.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on tox evaluation day (usually day 5)