| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 9.38 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 18.8 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 20.0 mg/kg/injection | 128.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 20.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 37.5 mg/kg/injection | 133.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 40.0 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 40.0 mg/kg/injection | 138.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 75.0 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 80.0 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 80.0 mg/kg/injection | 157.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 150.0 mg/kg/injection | 86.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 160.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | mean survival time | alkali diluted with saline | 160.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | mean survival time | alkali diluted with saline | 28.13 mg/kg/injection | 111.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | mean survival time | alkali diluted with saline | 56.25 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | mean survival time | alkali diluted with saline | 112.5 mg/kg/injection | 120.0 | Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5 |
| Q04DX003 (ip) | mean survival time | alkali diluted with saline | 225.0 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 30; 07/08 animals surviving on day 5 |
| Q04DX003 (ip) | mean survival time | alkali diluted with saline | 450.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 30; 02/08 animals surviving on day 5 |