In Vivo Screening Data Summary

NCI In Vivo Screening Data

Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (sc) mean tumor weight change saline with Tween-80 4.0 mg/kg/injection 25.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 4.0 mg/kg/injection 155.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 8.0 mg/kg/injection 5.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 8.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 16.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 01/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 16.0 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 32.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change saline with Tween-80 32.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11