In Vivo Screening Data Summary

NCI In Vivo Screening Data

Human Lung LX-1 Xenograft (intrarenal inoculation) in NU/NU Swiss (nude) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 6.25 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 68.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 40.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.5 mg/kg/injection 67.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 01/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 79.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 55.0 Antitumor endpoint evaluated on day 11; 03/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 11; 02/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11
Q01DX010 (sc) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 11; 00/03 animals surviving on day 11