In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (intramuscular) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) median survival time other 4.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 4.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 8.0 mg/kg/injection 91.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 8.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 10.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 50; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 16.0 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 16.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 34; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 20.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 50; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 32.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 32.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 34; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 39.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 49; 06/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 39.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 39; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 39.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 40; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 50; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 64.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 34; 07/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 64.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 34; 05/10 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 65.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 49; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 65.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 40; 03/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 65.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 39; 01/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 50; 00/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 108.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 49; 05/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 108.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 39; 00/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 108.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 40; 03/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 180.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 49; 00/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 180.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 40; 00/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 180.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 39; 00/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 10.0 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 20.0 mg/kg/injection 77.0 Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 39.0 mg/kg/injection 50.0 Antitumor endpoint evaluated on day 12; 06/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 39.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 40.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 12; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 65.0 mg/kg/injection 58.0 Antitumor endpoint evaluated on day 12; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 65.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 03/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 108.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 05/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 108.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 03/08 animals surviving on tox evaluation day (usually day 5)